April 3, 2025
Multifamily Therapy for Difficult-to-Treat Depression
Difficult-to-treat depression (DTD) represents one of the most complex psychiatric conditions in clinical practice. Unlike treatment-resistant depression (TRD), which focuses exclusively on the failure to respond to antidepressants, DTD encompasses a broader range of factors that influence treatment effectiveness and therapeutic response, including: Psychiatric and medical comorbidities, such as anxiety, personality disorders, and chronic pain. Childhood trauma, often associated with